Rat brain osmolality during barbiturate anesthesia and global brain ischemia.
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چکیده
منابع مشابه
Rat brain osmolality during barbiturate anesthesia and global brain ischemia.
Ischemic brain damage can be partially ameliorated by barbiturate therapy applied postinsult. Catabolism-induced brain hyperosmolality during ischemia may contribute to the development of brain edema after restoration of circulation. To determine changes in brain osmolality during ischemia and the effect of barbiturate anesthetics in altering its course, we measured whole and regional (cerebral...
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BACKGROUND AND PURPOSE Thiopentone reduces CBF and metabolic rate. Still, it is widely used for sedation during MR spectroscopy. We investigated whether barbiturate anesthesia and preanesthetic fasting have an effect on metabolic ratios in proton MR spectroscopy of the brain. METHODS Eight healthy, consenting, male volunteers were studied twice in a random, crossover fashion. The study sessio...
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متن کاملBrain tissue pH after global brain ischemia and barbiturate loading in rats.
Studies were done on rats to determine whether thiopental loading after complete, transient, global brain ischemia causes more rapid postischemic normalization of brain tissue pH. Fifteen halothane-anesthetized rats were subjected to 16 min of complete global brain ischemia by a combination of systemic arterial hypotension (40 torr) and a high pressure (1500 torr) neck cuff. Brain tissue pH was...
متن کاملRegional differences in rat brain lipids during global ischemia.
BACKGROUND AND PURPOSE Membrane lipid degradation plays an important role in the pathogenesis of ischemic brain damage, but there is little information on changes in cerebrosides, sulfatides, and sphingomyelin. We studied regional changes in the quantities of these lipids during complete global brain ischemia in rats. METHODS Nitrous oxide-anesthetized rats were subjected to ischemia by a hig...
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ژورنال
عنوان ژورنال: Stroke
سال: 1978
ISSN: 0039-2499,1524-4628
DOI: 10.1161/01.str.9.3.249